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Showing posts with label Drugs. Show all posts
Showing posts with label Drugs. Show all posts

November 23, 2007

Pain Medications and Breastfeeding

Info on selected pain medications

The information summarized below is only a general overview of selected pain medications. For detailed information on the specific drugs or for information on drugs not listed here, please review the references listed below with your health care provider.

Info on selected medications used for pain relief
Name of medication
AAP approved?*
Pregnancy Risk Category**
Notes
Acetaminophen
(Tylenol)
Approved
B
L1
Aspirin
Caution
C (1st, 2nd trim.)
D (3rd trim.)
L3
Azapropazone
(Rheumox)
Approved
- L2
Butalbital
(Fioricet, Fiorinal, Bancap, Two-dyne)
NR D L3 2
Butorphanol
(Stadol)
Approved
B (1st, 2nd trim.)
D (3rd trim.)
L3
Celecoxib
(Celebrex) (FDA safety info)
NR C L2
Codeine
(in Tylenol #3, #4)
Approved
C
L3
Colchicine
Approved
D L4
Diclofenac
(Cataflam, Voltaren)
NR B L2
Fentanyl
(Sublimaze)
Approved
B L2
Flurbiprofen
(Ansaid, Froben, Ocufen)
NR B (1st, 2nd trim.)
C (3rd trim.)
L2
Hydrocodone
(Lortab, Vicodin)
NR B L3 4
Hydromorphone
(Dilaudid)
NR C L3 5
Ibuprofen
(Advil, Nuprin, Motrin, Pediaprofen)
Approved
B (1st, 2nd trim.)
D (3rd trim.)
L1
Indomethacin
(Indocin)
Approved
B (1st, 2nd trim.)
D (3rd trim.)
L3
Ketorolac
(Toradol, Acular)
Approved
B (1st, 2nd trim.)
D (3rd trim.)
L2
Meperidine
(Demerol)
Approved
B L2;
L3 early postpartum
6
Methadone
(Dolophine)
Approved
B L3 7
Morphine
(Duramorph, Infumorph, Epimorph, MS Contin)
Approved
B L3 8
Nalbuphine
(Nubain)
NR B L2
Naproxen
(Anaprox, Naprosyn, Naproxen, Aleve)
Approved
B
L3;
L4 for chronic use
Nefopam
(Acupan)
Approved
-
NR
Oxycodone
(Tylox, Percodan,Oxycontin, Roxicet, Endocet, Roxiprin, Percocet)
NR B L3 10
Pentosan polysulfate
(Elmiron)
NR B L2
Piroxicam
(Feldene)
Approved
B L2
Propoxyphene
(Darvocet N, Propacet, Darvon)
Approved
C L2 11
Rofecoxib
(Vioxx)
Withdrawn from the market 12
Secobarbital
(Seconal)
Approved
D L3 13
Tolmetin
(Tolectin)
Approved
C L3
Tramadol HCL
(Ultram, Ultracet)
NR C L3 14
Valdecoxib
(Bextra) (FDA safety info)
Withdrawn from the market more


* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.

** Per Medications' and Mothers' Milk by Thomas Hale, PhD (2004 edition).

Lactation Risk Categories Pregnancy Risk Categories
  • L1 (safest)
  • L2 (safer)
  • L3 (moderately safe)
  • L4 (possibly hazardous)
  • L5 (contraindicated)
  • A (controlled studies show no risk)
  • B (no evidence of risk in humans)
  • C (risk cannot be ruled out)
  • D (positive evidence of risk)
  • X (contraindicated in pregnancy)
NR: Not Reviewed. This drug has not yet been reviewed by Hale.
  1. Aspirin use is discouraged in children and nursing mothers due to the risk of Reye's syndrome and internal bleeding.
  2. Fioricet (Fiorinal, Bancap, Two-dyne) contains acetaminaphen or asprin, caffeine, and butalbital. Per Hale, baby should be observed for sedation.
  3. Hale suggests weakened or premature infants be observed for sedation and apnea.
  4. Hale suggests newborns be observed for sedation, apnea, constipation.
  5. Per Hale, use of frequent, higher dose may result in infant sedation.
  6. Per Hale, Meperidine use during labor or early postpartum has been associated with sedation, poor sucking reflex, and neurobehavioral delay in infants.
  7. Per Hale, observe infant for sedation, respiratory depression, addiction, withdrawal syndrome.
  8. Per Hale, higher doses may result in infant sedation.
  9. Per Hale, should be used with caution due to its long half-life and its effect on baby's cardiovascular system, kidneys and GI tract; short-term, infrequent or occasional use is not necessarily incompatible with breastfeeding.
  10. Roxicet, Endocet, Roxiprin, Percocet also contain acetaminophen. Per Hale, observe infant for sedation.
  11. Per Hale, observe infant for sedation.
  12. Per Hale, observe infant for GI cramping, distress, diarrhea.
  13. Per Hale, observe infant for sedation.
  14. Per Hale, observe infant for sedation.

Migraine Medications and Breastfeeding

Info on selected migraine meds

The information summarized below is only a general overview. For detailed information on the specific drugs, please review the references listed below with your health care provider.

Info on selected meds used for migraine prevention and/or pain relief
Name of medication
AAP approved?*
Notes
Acetaminophen (Tylenol)
yes
L1 (safest)
Almotriptan malate (Axert)
not reviewed
not reviewed
Amitriptylline (Elavil, Endep)
no
L2 (safer)
Asprin
no
L3 (moderately safe)
Butalbital (Fioricet, Fiorinal, Bancap, Two-dyne)
not reviewed
L3 (moderately safe)
Caffeine
yes
L2 (safer)
Codeine
yes
L3 (moderately safe)
Ergot alkaloids (DHE 45, Cafergot, Wigraine, Ergostat, Ergomar)
no
L4 (possibly hazardous)
Frovatriptan (Frova, Migard)
not reviewed
not reviewed
Ibuprofen (Advil, Motrin)
yes
L1 (safest)
Isometheptene Mucate (Midrin)
not reviewed
L3 (moderately safe)
Ketorolac (Toradol, Acular)
yes
L2 (safer)
Metoprolol (Toprol-XL, Lopressor)
yes
L3 (moderately safe)
Naproxen (Anaprox, Naprosyn, Aleve)
yes
L3 (moderately safe);
L4 (possibly hazardous) for chronic use
Naratriptan (Amerge)
not reviewed
L3 (moderately safe)
Nifedipine (Adalat, Procardia)
yes
L2 (safer)
Propranolol (Inderal)
yes
L3 (moderately safe)
Rizatriptan (Maxalt) not reviewed L3 (moderately safe) 14
Sumatriptan (Imitrex)
yes
L3 (moderately safe)
Valproic Acid (Depakene, Depakote)
yes
L2 (safer)
Verapamil (Calan, Isoptin, Covera-HS)
yes
L2 (safer)
Zolmitriptan (Zomig, Zomig-ZMT)
not reviewed
L3 (moderately safe)
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
** Per Medications' and Mothers' Milk by Thomas Hale, PhD (2002 edition).

1. Almotriptan malate (Axert) is a new drug in the same category as Sumatriptan (Imitrex). It has a relatively short half-life (3-4 hours) and reaches peak plasma level 2-4 hours after administration (see pharmacologic info). No data is currently available regarding its transfer into human milk.

2. Amitriptylline (Elavil, Endep) is listed by the AAP as a "drug whose effect on nursing infants is unknown but may be of concern." However, several studies have shown that this drug is secreted into breastmilk in very small amounts and per Hale, "no untoward effects have been reported in several studies" of breastfed babies whose mothers took this med.

3. Aspirin use is discouraged in children and nursing mothers due to the risk of Reye's syndrome and internal bleeding. The AAP lists it as a "drug associated with significant side effects and should be given with caution."

4. Fioricet (Fiorinal, Bancap, Two-dyne) contains acetaminaphen or asprin, caffeine, and butalbital. Per Hale, baby should be observed for sedation.

5. Codeine (in Tylenol #3 and #4) is AAP approved for nursing mothers but, per Hale, is probably not a good choice for mothers of premature or weakened infants. Hale suggests weakened or premature infants be observed for sedation and apnea .

6. Per Hale, use of ergot alkaloids during lactation should be strongly discouraged. The AAP lists them as "drugs associated with significant side effects and should be given with caution." Excessive dosing and prolonged use may inhibit lactation. Long term exposure is contraindicated.

7. Because better drugs exist for migraine therapy, Hale suggests that Isometheptene Mucate (Midrin) is probably not a good choice for breastfeeding mothers.

8. Per Hale, although the levels of this drug transferred to the infant are probably too low to be clinically relevant, close supervision should be used. No pediatric concerns have been reported in several studies, but observe infant for hypotension, weakness, bradycardia.

9.Aleve (Naproxen) is AAP-approved for nursing mothers, but (per Hale) should be used with caution due to its long half-life and its effect on baby's cardiovascular system, kidneys and GI tract; short-term, infrequent or occasional use is not necessarily incompatible with breastfeeding.

10. Per Hale, no pediatric concerns reported via milk, but observe infant closely for changes in liver enzymes, clinical status and platelet levels.

11. Per Hale, no pediatric concerns reported via milk, but observe infant for hypotension, bradycardia, weakness.

12. Per Hale, zolmitriptan is structurally similar to sumatriptan. It is currently unknown how much of this drug is secreted into human milk.

13. More info on frovatriptan:

14. It is currently unknown how much of this drug is secreted into human milk. It is concentrated in rodent milk, so caution is recommended.

Cold and Allergy Remedies Compatible with Breastfeeding

he common cold will usually run its course within 7 to 14 days. There are many natural remedies and over the counter products that are compatible with breastfeeding.


Natural Remedies
General
  • Rest. Drink lots of water and take hot baths. Run a humidifier.
  • Take in extra vitamin C from foods, juices or in supplement form.
  • Echinacea is generally recognized to be safe for nursing moms.
  • Garlic eaten raw, cooked, or taken as a supplement can help. Raw is always best, though it's hardest to get down.
  • Homeopathic remedies, are considered safe for nursing moms.
  • OMT is a very gentle form of osteopathic manipulation, which can enhance the immune system, and help keep the fluids draining from the head and neck so bacteria and viruses are less likely to be able to grow. This can help to reduce or even prevent chronic ear and respiratory infections. OMT has been shown to have a dramatic effect on fluid in the ears, and works well on any type of upper respiratory infection.
Head congestion
  • Use a saline nasal spray
  • Steam treatments:
    • Boil a pot of water, remove from the stove and (optional) add a few drops of essential oils (for example: eucalyptus, sage and balsam). Drape a bath towel over your head and breathe deeply for 5 minutes. Do this 2 or 3x a day until symptoms subside.
    • Put two inches of apple cider vinegar in a pan and heat until it begins to steam. Inhale the vapor. If the vapor is too strong, add a little water. Repeat as needed.
  • Essential Oils: Place a drop or two of either eucalyptus or peppermint essential oil on a cotton ball or handkerchief and hold near the nose while breathing deeply.
    • A couple of cautions: Do not use the oil in the nose - it can cause swelling. Do not use peppermint oil or menthol (one of the main components in peppermint oil) or camphor on or near the breast where baby might ingest it, and do not apply directly on the skin of a baby or young child. There have been cases where the direct application of menthol or camphor products (for example, Vicks VapoRub™) to baby's skin resulted in severe breathing difficulties or liver problems (see info on colds and congestion in baby).
  • Cayenne pepper: Sprinkle it on your food, or put a quarter teaspoon in a glass of water and drink.
  • Drink fenugreek tea to relieve head and chest congestion and cough.
  • Massage can help with sinus problems
  • What To Do When You Have Sinus Pain by Allison Ishman
Chest congestion
  • Anise steam treatment: Boil a pot of water, remove from the stove and add about 3 teaspoons of dried anise. Drape a bath towel over your head and breathe deeply for 5 minutes. Do this 3x a day to help keep the chest clear.
  • Drink fenugreek tea to relieve head and chest congestion and cough.
Sore, itchy throat and/or cough
  • Drink strong black tea (use 2 tea bags per cup).
  • Drink hot lemonade with honey. Or make a mixture of one part lemon juice and two parts honey. Sip throughout the day.
  • Drink fenugreek tea to relieve head and chest congestion and cough.
  • Use Zinc gluconate lozenges, but avoid taking large amounts of zinc for more than seven days, because it can interfere with other minerals in the body.
  • Salt water gargle:
    Mix a 1 tablespoon of salt in eight ounces of warm water. Gargle the whole mixture (don't swallow) several times a day.
  • Apple-cider vinegar and water gargle.
    Mix 1-6 teaspoons (1/3 - 2 tablespoons) vinegar in a glass of water; you can mix it as strong as you can stand it. Gargle one mouthful (swallow afterward or spit it out). Repeat twice. Do this every hour, or as needed.
  • Slippery elm bark can help with sore throat and cough. It comes in herbal cough drops and throat lozenges (check the other ingredients!), or you can make a tea. For tea, use 1 to 3 teaspoons of powdered bark per cup, boil and simmer 15 minutes. Up to 3 cups per day.
  • Chamomile tea gargle (you can also drink the tea)
  • Goldenseal tea gargle (use every 2 hours or as needed)

Medications generally regarded as safe
General guidelines
  • Treat only the symptoms you have: avoid a combination medicine when a single one will do the job.
  • Short-acting forms of drugs (6 hours or less) are generally better than the long-acting varieties (but see the info below on the nonsedating antihistamines).
  • Use nasal spray instead of oral medications when possible (see below).
  • Take any medication right AFTER you nurse and only as needed.

The 2004 edition of Medications and Mothers' Milk by Thomas Hale, PhD has information on many cold medications (including specific guidance on combination products) in the Appendix (p. 874-889). Many of the active ingredients in cold and allergy medications are listed below.

Cough & sore throat meds
  • Sore throat sprays or lozenges are generally considered safe, as are cough drops. Avoid eating excessive amounts of cough drops containing menthol. Large amounts of menthol can reduce milk supply.
  • Many forms of Robitussin, Delsym and Benylin are considered compatible with breastfeeding. Always check the active ingredients, as there are many versions.
Cough Medicines
Name of medication
AAP approved?*
Codeine
yes
L3 (moderately safe)
Dextromethorphan
not reviewed
L1 (safest)
Guaifenesin
not reviewed
L2 (safer)
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
** Per Medications' and Mothers' Milk by Thomas Hale, PhD (2002 edition)

Pain meds

Both Advil/Motrin (Ibuprofen) and Tylenol (Acetaminophen) are considered compatible with breastfeeding and are approved by the AAP for use in nursing moms.

Aleve (Naproxen) is also AAP-approved for nursing mothers, but (per Hale) should be used with caution due to its long half-life and its effect on baby's cardiovascular system, kidneys and GI tract; short-term, infrequent or occasional use is not necessarily incompatible with breastfeeding.

Aspirin use is discouraged in children and nursing mothers due to the risk of Reye's syndrome and internal bleeding.

See Pain medications and breastfeeding for more information.

Eye drops

Eye drops designed for cold/allergy symptom relief are considered compatible with breastfeeding.

Nasal sprays or gels

Nasal sprays are generally considered compatible with breastfeeding.

Of the preparations available for treatment of allergic symptoms, the nasal steroids (e.g., Flonase, NasalCrom) are considered to be, by far, some of the most effective and safest to use in breastfeeding moms. Although there is so far no data specifically on these intranasal steroids, it is known that the plasma levels of the drug are extremely low, and thus milk levels would be even lower.

Nasal sprays containing oxymetazoline are probably not a problem, but oxymetazoline is long-acting and thus not the first choice for nursing mothers. A shorter acting alternative is phenylephrine.

Zicam, a homeopathic nasal gel containing ionic zinc gluconate, is generally considered to be compatible with breastfeeding. Zicam contains small amounts of zinc (Zincum Gluconicum) - 266 micrograms per squirt; in one study (Mossad 2003) the daily dosage used was 2.1 mg per day. Zinc is considered compatible with breastfeeding, particularly in small amounts (excessive amounts are not a good idea, for mom's sake rather than baby's). In addition, nasal sprays/gels are generally a better choice for nursing moms as compared to oral medicines. The amount of systemic absorption of nasal sprays/gels is minimal compared to oral ingestion. Although not related to lactation, it should be noted that there are reports of loss of smell resulting from the use of intranasal zinc gluconate (see Jafek BW, Linschoten MR, Murrow BW. Anosmia after intranasal zinc gluconate use. Am J Rhinol. 2004 May-Jun;18(3):137-41).

Nasal Sprays
Name of medication
AAP
approved?*
Beclomethasone (Vanceril, Beclovent, Beconase, Vancenase)
not reviewed
L2 (safer)
Cromlyn sodium (Nasalcrom)
not reviewed
L1 (safest)
Fluticasone (Flonase)
not reviewed
L3 (moderately safe)
Mometasone (Nasonex)
not reviewed
L3 (moderately safe)
Phenylephrine (in some forms of Sinex and Neo-Synephrine)
not reviewed
L3 (moderately safe)
Triamcinolone Acetonide (Nasacort)
not reviewed
L3 (moderately safe)
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
** Per Medications' and Mothers' Milk by Thomas Hale, PhD (2002 edition)

Decongestants

Both pseudoephedrine and phenylephrine are generally considered to be safe for the breastfed baby, but pseudoephedrine may reduce milk supply.

Pseudoephedrine & milk supply: Thomas Hale Ph. D., a renowned breastfeeding pharmacologist (Breastfeeding Pharmacology), notes that "breastfeeding mothers with poor or marginal milk production should be exceedingly cautious in using pseudoephedrine" and that "it is apparent that mothers in late-stage lactation may be more sensitive to pseudoephedrine and have greater loss in milk production" (Medications and Mother's Milk, 2006 edition).

Dr. Hale is referring to this study: Aljazaf K, et. al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003 Jul;56(1):18-24.

If you do take pseudoephedrine and notice a drop in milk supply (many moms do not, but research shows that it can decrease milk supply by as much as 24%), simply stop the medication and take measures to increase milk supply - the problem should resolve fairly quickly.

Be very cautious about taking pseudoephedrine on a regular basis, as it has the potential to permanently decrease your milk supply. Regular use of pseudoephedrine (120 mg/day) has occasionally been used to decrease milk production in moms with overproduction, where the usual methods to regulate milk production were not working.

Many meds have been reformulated so they no longer contain pseudoephedrine -- they're using phenylephrine instead. Per Hale, "Because of pseudoephedrine's effect on milk production, many have concerns that phenylephrine may suppress milk production as well. There is no evidence that this occurs at all."

Decongestants
Name of medication
AAP approved?*
Phenylephrine
not reviewed
L3 (moderately safe)
Pseudoephedrine (Sudafed, Actifed)
yes
L3 (moderately safe) for acute use
L4 (possibly hazardous) for chronic use due to potential for decreasing milk supply
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
** Per Medications' and Mothers' Milk by Thomas Hale, PhD (2006 edition)

Antihistamines

Mom's use of Benadryl and Chlor-Trimeton are generally regarded to be compatible with breastfeeding, but always double-check the active ingredients. Monitor your infant for possible drowsiness if you use an antihistamine. The non-sedating antihistamines (below) are generally preferred and are less likely to sedate baby.

The ingredients of Claritin, Claritin-D, Allegra, Allegra-D, Actifed (the decongestant pseudoephedrine plus triprolidine) and Seldane have been approved by the AAP for use by nursing moms. Loratadine (Claritin) has been studied and the amount of loratadine that passes into breastmilk is extremely low. Claritin-D and Allegra-D have pseudoephedrine added (which is AAP approved, but see above about possible effect on milk supply). Dr. Hale has said that he prefers the nonsedating antihistamines (even though they are long-acting) over the sedating allergy medications.

Zyrtec is also generally considered to be compatible with breastfeeding. It is commonly used by nursing moms, although its levels in milk are not known. Hale rates Zyrtec in the lactation risk catagory L2 (safer).

Clarinex (desloratadine): Desloratadine is another name for descarboethoxyloratadine, which is the main metabolite (breakdown product) of Claritin (loratadine). Per one study (Hilbert J, Radwanski E, Affrime MB et al. Excretion of loratadine in human breast milk. J Clin Pharmacol.1988:28:234-9), 0.019% of the descarboethoxyloratadine was transferred into breastmilk. Since Claritin (and thus its active metabolites, too) is considered safe for nursing moms (it's AAP approved, in fact), Clarinex should not be a problem either.

Milk supply: A common concern is that antihistamines might lower milk supply but, per Dr. Thomas Hale, there is no current research supporting this belief. If you feel that your supply has decreased, it could simply be a byproduct of decreased nursing frequency or dehydration due to your illness.

If you feel that a medication is the cause of a sudden drop in milk supply, then stop taking (or decrease your use of) the medication - if the med is indeed the cause, then supply should increase again soon after you stop taking it. When using an antihistamine, it can be helpful to step up your fluid intake quite a bit. As with any medication, take it only as needed, and discontinue use as soon as you can.

Antihistamines
Name of medication
AAP approved?*
Brompheniramine
not reviewed
L3 (moderately safe)
Chlorpheniramine (Chlor-Trimeton)
not reviewed
L3 (moderately safe)
Cetirizine (Zyrtec)
not reviewed
L2 (safer)
Dexbrompheniramine maleate
with d-isoephedrine
yes
not reviewed
Diphenhydramine (Benadryl)
not reviewed
L2 (safer)
Doxylamine not reviewed L4 (possibly hazardous)
Fexofenadine (Allegra)
yes
L3 (moderately safe)
Loratadine (Claritin)
yes
L2 (safer)
Terfenadine (Seldane)
yes
not reviewed
Triprolidine (Actidil, Actifed)
yes
L1 (safest)
* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
** Per Medications' and Mothers' Milk by Thomas Hale, PhD (2002 edition)

Prescription Drugs Used for Increasing Milk Supply

By Kelly Bonyata, IBCLC

There are several prescription drugs that have been used to increase milk supply: Metoclopramide (Reglan), Domperidone (Motilium), and sulpiride (Eglonyl, Dolmatil, Sulpitil, Sulparex, Equemote).

The presence of an appropriate level of the hormone prolactin permits lactation to proceed normally. When a mother has low prolactin levels, milk supply may be affected. Prolactin levels are primarily regulated by inhibition: the presence of prolactin-inhibiting factors (dopamine is the principal one) keep prolactin levels in check. The drugs used for increasing milk supply work by blocking dopamine, which results in an increase in prolactin levels. These drugs do not work in all women and would not be expected to increase milk production in a woman who already has normal (high) prolactin levels.

Reglan has often been used in the U.S.. One major side-effect of Reglan is severe depression; it is contraindicated in moms with a history of depression, and all moms who take this should keep an eye out for signs of depression. One of my sources advises all adoptive mothers to stay away from Reglan, since it has caused serious depression/anxiety in moms regardless of previous history. This depression side effect usually develops over 3-4 weeks, and goes away if mom discontinues the Reglan. Other side effects include diarrhea, sedation, gastric upset, nausea, seizures and extrapyramidal effects (twitching, etc.)

Domperidone has been used successfully in Canada and other areas of the world, and has significantly fewer side effects than Reglan. It has been approved by the American Academy of Pediatrics for use in breastfeeding mothers, and has been given Lactation Risk Category L1 ("safest") in the 2004 edition of Medications and Mothers' Milk. It is not widely available in the U.S. - you may be able to get a compounding pharmacy to make it for you if your doctor prescribes it, or may also be able to order it from Canada or other countries). See the links below for more info.

Sulpiride is commonly used in various countries including Zimbabwe, South Africa and Chile. The primary use for sulpiride is for schizophrenia (it is an antipsychotic and antidepressant), but it also increases serum prolactin levels and thus can enhance breast milk yield.

Prescription drugs that stimulate lactation
Name of medication
AAP approved?*
Domperidone (Motilium, Motilidone)
yes
L1 (safest)
Metoclopramide (Reglan)
no
L2 (safer)
Sulpiride (Dolmatil, Sulparex, Sulpitil, Eglonyl, Equemote)
not reviewed
L2 (safer)

* Per the AAP Policy Statement The Transfer of Drugs and Other Chemicals Into Human Milk, revised September 2001.
** Per Medications' and Mothers' Milk by Thomas Hale, PhD (2004 edition)
† Per the AAP, classified as "Drug whose effect on nursing infants is unknown but may be of concern." AAP notes on this drug: "reported or possible effect: none described; dopaminergic blocking agent"; "Drug is concentrated in human milk relative to simultaneous maternal plasma concentrations." Hale reports results of a number of studies and indicates that domperidone is preferred but not available in the US. He notes that no pediatric concerns have been reported via milk, and that this drug is commonly used in pediatrics.